With the potential for Buffalo to get ahead of the game script, Allen will have more chances to run the ball, as will running back James Cook. Plus, Allen has topped this prop in two of the three matchups against the Chiefs over the past three years, so look for that trend to continue.

The Buffalo Bills will face the Kansas City Chiefs on Sunday, November 17, 2024 at Highmark Stadium. We provide DFS stacks and value plays for this matchup below.

The Bills host the Chiefs in what is being billed as the game of the year in the NFL. Here is Sal Maiorana's in-depth preview.

The biggest game of the NFL season is taking place in Orchard Park on Sunday, as the Kansas City Chiefs head up to Highmark Stadium to take on the Buffalo Bills (4:25 p.m. ET on CBS) in a battle of the top two teams in the AFC.

Continue reading for more insights regarding the Bills vs. Chiefs matchup, including stats, leaders and a predicted winner. Don't miss a touchdown this NFL season. Catch every score with NFL RedZone on Fubo.

Josh Allen vs. Patrick Mahomes, playoff games and exciting regular seasons games have made this a premier game on the NFL schedule.

The game of the week is in the late afternoon slate this week. The undefeated Chiefs will travel to Buffalo to battle the 8-2 Bills. Patrick Mahomes is 4-3 against the Bills in his career, while Josh Allen is 3-1 against the Chiefs.

ESPN believes that Buffalo Bills wide receiver Khalil Shakir could be in for a big game when his team hosts the Kansas City Chiefs in Week 11.