The series chronicles the early evolution of the Bene Gesserit order into a superpowered mystical sisterhood with great political power.

Prophecy centers entirely around the origins of the Bene Gesserit, known only as "the Sisterhood" in the show. However, there's a very simple reason for that. "The Sisterhood at its inception is not called the Bene Gesserit,

Prophecy refer to? Before the show’s first episode, the answer seemed obvious and easy. The prequel series takes place 10,000 years before the birth of Paul Atreides. That long ago era marked the early days of the Sisterhood that put in motion a grand plan to breed the super being of Frank Herbert’s seminal novel.